Polynucleotides

While standard skin boosters like Profhilo primarily utilize high concentrations of Hyaluronic Acid (HA) to bind water and flood the extracellular matrix with moisture, polynucleotides function as a biological tissue regenerator. Formulated from ultra-pure fractions of salmon DNA (known clinically as PDRN), polynucleotides do not simply hydrate the tissue from the surface. Instead, they interact directly with your cells by binding to A2A adenosine receptors. This signals your native fibroblasts to rapidly produce brand new, high-quality Type I collagen and elastin, while lowering localized inflammation. They cure the underlying skin degradation rather than temporarily masking it with moisture.

Yes, polynucleotides are exceptionally safe and have been utilized in clinical wound-healing procedures for over three decades. The DNA fractions are extracted from salmon germ cells, then undergo a rigorous, multi-stage purification protocol that strips away all active proteins and cellular debris. This leaves behind a completely pure, non-immunogenic polymer chain that is highly bio-compatible with human skin cells. Because all genetic material is entirely removed during processing, there is no risk of transmitting species-specific diseases or triggering an allergic reaction. Please note: as a precautionary measure, this treatment is not suitable for individuals with a verified, severe systemic allergy to fish or seafood.

Absolutely. In fact, the periocular zone (the delicate eye area) is where polynucleotides deliver some of their most transformative clinical results. Traditional dermal fillers pose high risks when placed under the eyes, frequently causing fluid retention, chronic swelling (malar oedema), or a blue tint beneath the skin (the Tyndall effect). Polynucleotides eliminate these complications entirely. Because the fluid contains no cross-linked gels, it can be safely micro-injected right up to the lash line to repair thinning skin structure, stimulate localised angiogenesis (blood vessel health) to erase dark vascular circles, and naturally lift hollow under-eye troughs.

Because polynucleotides depend on a biological "salvage pathway" to repair your cells, your transformation happens progressively rather than overnight. To achieve a complete cellular reset, an initial course of 3 sessions, spaced 3 to 4 weeks apart, is mandatory. While minor texture smoothing can be observed within two weeks, your ultimate skin-tightening and pigmentation-clearing results mature over 2 to 3 months following your final appointment. This is the exact timeline required for your newly activated fibroblasts to grow and lay down a dense, resilient network of structural proteins.

Social downtime is minimal, usually resolving within 24 to 72 hours. Because polynucleotides are meticulously deposited as micro-droplets directly into the upper dermis, you will leave the clinic with small, visible bumps at the injection sites. Due to the lower water-binding properties of PDRN compared to heavy HA gels, these bumps typically self-diffuse and disappear much faster than standard skin boosters—often within 24 to 48 hours. Mild localised swelling and minor pin-prick bruising can occur around the thin skin of the eyes but will fade rapidly and can be safely concealed with clean mineral makeup after 24 hours.